What is Hyaluronidase?

Hyaluronidase is also known as Hylase, it is a prescription-only enzyme that dissolves hyaluronic acid.

Hyaluronidase can dissolve many Dermal Fillers.

Many Dermal Fillers consist mostly of synthesized hyaluronic acid; this component of the Dermal Filler can therefore be broken down with Hyaluronidase to remove most of the filler. The enzyme is injected in the same way as any other injectable treatment and the effects can be seen after several minutes, but it takes a few days to see the full results. Hyaluronidase has been used by doctors for injections for years, most commonly to assist the spread of local anaesthetic solutions.

Dermal Fillers that can be dissolved include:


Hyaluronidase is ineffective on Radiesse, Ellansé, Artefill, Silicone, Sculptra or other non-HA fillers.

Who performs the Hyaluronidase treatment?

Dr Teri Johnson has years of experience performing this advanced correction treatment on patients who have had fillers.

Dr Johnson provides this treatment for her Dermal filler patients only. Otherwise, she will need a referral from the injector detailing the dermal filler treatment, the product, the volume and the treatment areas.

Does Hyaluronidase treatment hurt?

The treatment is a little uncomfortable, similar to other injectable procedures.

To minimize your discomfort, Dr Teri uses topical anaesthetic on the skin to numb the area before the injection.

She also mixes the Hyaluronidase with lidocaine, a local anaesthetic, so the treated area goes numb during the procedure.

How many filler-dissolving treatment sessions will I require?

You may not need more than one treatment. Depending on the extent of the filler and the volume of excess filler that we are trying to dissolve, you may need another treatment between 3 and 5 days later.

Which areas can be it treat?

Hyaluronidase can treat most areas where a dermal filler has been placeinjected including:

  • Nasolabial lines
  • Lips
  • Perioral lines (smokers’ lines around the mouth)
  • Chin
  • Cheek
  • Under eye area

Are there side effects of Hyaluronidase filler dissolving treatment?

There are few reported side effects with Hyaluronidase, slight bruising being the most common (as with any injections); this is usually minimal.

Localised allergic reactions to the enzyme can occur. For this reason, you will need a patch test at least 24 hours before the procedure.

This enzyme is not recommended for patients with a history of allergy to bee venom or who suffer from anaphylaxis.

How much does a Hyaluronidase treatment cost?

This advanced procedure costs between £250 and £500.

How do I book a treatment?

If you have a treatment elsewhere, we encourage you to contact the medical practitioner who performed your treatment. They will be in the best position to treat you based on their first-hand knowledge about your treatment. All aesthetic practitioners should be able to provide this treatment if they are performing Dermal Fillers.

If they are unable to help you we would need a verbal and written referral from the practitioner. So we can perform an assessment of the problem, assess the medical records detailing the treatment, the product used, the product volumes and placement. Provided it was in our scope of practice and subject to arranging insurance on a case by case basis we would do our up-most to help, otherwise we can sign post to an expert in dealing with more complex problems.

Please email middlewichclinic@aol.com should you wish to refer a client for this procedure.